nexgard

Sa santé, les soins à lui apporter. Problèmes génétiques.

nexgard

Messagede celine le Lun 28 Mar 2016 16:44

bonjour
je voulais savoir si quelqu'un parmis vous avez deja essayer?
et si il y'avais un risque avec le mdr1
celine
 
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Re: nexgard

Messagede Patrick le Lun 28 Mar 2016 21:47

Bonsoir Céline,

Nexgard, produit par Merial, et Bravecto produit par Merck, utilisent 2 molécules très proches l'une de l'autre qui sont issues de la famille des isoxazolines. Il faut noter qu'il s'agit de pesticides agricoles.

Concernant MDR1: Aucun danger, le test a été réalisé sur des colleys mutés à 10 fois la dose sans le moindre effet visible.

Maintenant... Concernant d'autres effets sur la santé... Là, mystère.
Il s'agit quand même de pesticides agricoles que le chien va avaler. De plus, la persistance dans l'organisme est très longue, jusqu'à 3 mois.
Les scientifiques mettent en garde sur leur utilisation:
"Safety of isoxazolines
Published information on safety and toxicity of isoxazolines is still very scarce.
Due to their recent introduction there is very little knowledge on tolerance in different dog breeds or in young, old or otherwise weak animals."


Que l'on traduira par:
"Les informations publiées sur la sécurité et la toxicité des isoxazolines sont encore très rares.
En raison de leur introduction récente, il y a très peu de connaissances sur la tolérance chez les différentes races de chien, chez les jeunes , les chiens âgés ou les animaux fragilisés."


En conclusion, je dirais "méfiance avec ce produit".
Perso, je préfère les produits externes (pipettes) où là, la substance active, et nocive, reste sur la peau.
Patrick
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Re: nexgard

Messagede LouLou le Ven 1 Avr 2016 20:32

Bonjour à tous !

Merci pour ces info Patrick , mon vétérinaire.
m'a fait donner nexguard à mes deux colleys cet hiver .
Ils avaient attrapé des puces en plein mois de décembre ... :evil:
première fois de ma vie ...
Il avait fait attention au risque MDR 1 , mais comment as t on les info du laboratoire sur les tests réalisés sur colley ???
LouLou
 
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Re: nexgard

Messagede Patrick le Ven 1 Avr 2016 22:06

Bonsoir Loulou,

16 colleys mutés pour MDR1 ont pris part à l'étude.
8 ont reçu 3 fois la dose normale. Les 8 autres ont servi de témoins.
Tous les colleys ont été surveillés cliniquement jusqu'à 28 jours après le traitement.
Aucun effet indésirable n'a été observé.

Voici l'étude scientifique réalisée sur le fluralaner (Bravecto):
http://www.ncbi.nlm.nih.gov/pmc/article ... 5-7-86.pdf
Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(−/−) Collies after oral administration
Methods
Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Eight Collies received fluralaner chewable tablets once at a dose of 168 mg/kg; eight sham dosed Collies served as controls. All Collies were clinically observed until 28 days following treatment.
Results
No adverse events were observed subsequent to fluralaner treatment of MDR1(-/-) Collies at three times the highest expected clinical dose.


Quant au Nexgard, dont la molécule, l'afoxolaner, est quasi identique au fluralaner, je n'ai pas le détail de l'étude scientifique réalisée, mais j'ai les conclusions qui sont disponibles dans le document d'approbation européen.
A 10 fois la dose thérapeutique, aucun effet indésirable n'a été observé chez des colleys sensibles à l'ivermectine, donc mutés pour MDR1.
Ils ont juste remarqué une plus longue persistance dans l'organisme…. C'est normal, on aurait pu leur dire… La mutation MDR1 retarde l'élimination des molécules toxiques…

C'est ici:
http://www.ema.europa.eu/docs/en_GB/doc ... 164068.pdf
CVMP assessment report for NexGard

Page 7
In ivermectin sensitive Collies, Cmax was markedly higher at a dose of 25 mg/kg bw compared to studies using Beagles.......
Also, afoxolaner appeared to have a longer half-life in Collies (mean of 33 days at a dose of 25 mg/kg bw) than in Beagles. However, there were no serious adverse events observed following the dose of 25 mg/kg bw (i.e. 10x the therapeutic dose) administered to Collie dogs.

Page 10
In an exploratory pharmacokinetic/safety study, Collies sensitive to ivermectin (MDR1-Collies) were treated orally with 25 mg afoxolaner/kg bw.
Afoxolaner was generally well tolerated confirming that P-glycoprotein does not play a role in afoxolaner transport.


Patrick
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Re: nexgard

Messagede Catrin' le Sam 2 Avr 2016 11:58

Bonjour,

Pour ma part, je ne dirai JAMAIS qu'un produit est sans danger: qu'il soit avalé ou déposé sur la peau, s'il est capable de tuer puces, tiques, vers etc., il N'est PAS inoffensif et on lit tous les jours des histoires dramatiques!
En voici une, à titre d'exemple:


Two more dead dogs in Brazil
Vet med student this time!
My two dogs died after using Bravecto
MSD Animal Health -Intervet
Niterói - RJ Thursday, January 14, 2016 - 14:26
I want to notify them that after medicated with Bravecto according to the correct weight, my two dogs one SRD 12 years and Pinscher of 5, died. One died on 01.09.2016 and 01.10.2016 another the next day. The two were apparently very good health! I was medicating that after the next night my pinscher died down the stairs, had a massive heart attack. I rushed to the vet in front of my house, and nothing more could be done. During the day he noticed with dilated pupils and alertness. The other died the next night, the SAME way. On the day she was apathetic, and even urinate in his own bed, something he never did. One day after Bravecto vomited twice. Both died with a cry of pain, and his heart with the altered heart rate, accelerated LOT. It was the worst pain of my life, see my two dogs dying from a drug that I myself gave, and the "best of breed". I ask you kindly to contact for this to be clarified once again, and that you take note that there are possibilities of the drug to be having potential failures.
I'm Veterinary Medicine student and nothing I could do to it to be avoided. They are gone. I and my mother lost our two joys of our house!
Catrin' & Le Pack
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Re: nexgard

Messagede Patrick le Sam 2 Avr 2016 17:18

Bien sûr, Catherine, on est d'accord.
J'ai simplement rapporté la conclusion des études faites par rapport à MDR1.
Je mets aussi en garde contre le manque de recul par rapport à des molécules qui viennent, à l'origine de chez…. Nissan Chemical et DuPont de Nemours… Cherchez l'erreur.!!
Je trouve d'ailleurs que ce produit est donné trop facilement.
Je viens de voir que Zoetis (Pfizer) vient aussi de sortir son produit du nom de Simparica qui utilise une molécule du nom de sarolaner, de la même famille que les 2 autres.... Ils veulent aussi avoir leur part du gâteau.!
Dans tous les cas de figure, si j'étais véto, je conseillerais avant tout un produit externe, Frontline combo pour les puces, Advantix pour les tiques, etc.
Même si les spot-on ne sont pas inoffensifs, ils seront toujours largement moins nocifs qu'un produit avalé.
Il faut aussi prendre en compte le couple bénéfice/risque.
Patrick.
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Re: nexgard

Messagede LouLou le Sam 2 Avr 2016 17:45

Oui !

Pas très encourageant .

Je pense retourner à Advantix , qui est utilisé par voie externe , bien que le passage par la peau soit systémique.

dans ma région (Var ) nous avons tout : Leishmaniose , dirofilariose...
les puces étant moindre mal.

Et dans le Rhône , des tiques et la piroplasmose. :|

Question : utilisez vous des répulsifs "naturels " contre les moustiques ? lavande , géraniol ...en huiles essentielles ?
je me renseigne sur leur toxicité .
Car dit naturel ne dit pas sans danger.
LouLou
 
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Re: nexgard

Messagede Eireann le Sam 2 Avr 2016 17:52

Voici quelques exemples ou des étalons et des femelles ont pris Bravecto avant saillies.
Les résultats sont très inquiétants.


IS BRAVECTO SAFE FOR BREEDING DOGS?

BELOW YOU WILL FIND THE RESULTS OF THE STUDY DONE BY EMPLOYEES OF MSD FOR FDA APPROVAL AND ACTUAL CASES MSD HAS REPORTED TO THE EUROPEAN MEDICINE AGENCY ALONG WITH A FEW POSTS FROM THIS GROUP.

RESULTS OF STUDY FOR APPROVAL:
Bravecto was administered orally to intact, reproductively sound male and female Beagles at a dose of up to 168 mg/kg (equivalent to 3X the maximum label dose) on three to four occasions at 8-week intervals. The dogs in the control group (0X) were untreated. There were no clinically-relevant, treatment-related effects on the body weights, food consumption, reproductive performance, semen analysis, litter data, gross necropsy (adult dogs) or histopathology findings (adult dogs and puppies). One adult treated dog suffered a seizure during the course of the study (46 days after the second treatment). Abnormal salivation was observed on 17 occasions: in six treated dogs (11 occasions) after dosing and four control dogs (6 occasions). The following abnormalities were noted in 7 pups from 2 of the 10 dams in only the treated group during gross necropsy examination: limb deformity (4 pups), enlarged heart (2 pups), enlarged spleen (3 pups), and cleft palate (2 pups). During veterinary examination at Week 7, two pups from the control group had inguinal testicles, and two and four pups from the treated group had inguinal and cryptorchid testicles, respectively. No undescended testicles were observed at the time of necropsy (days 50 to 71).”

CASES REPORTED TO THE EUROPEAN MEDICINE AGENCY.

CASE ONE - ORGANS OUTISDE ABDOMINAL CAVITY
Suspected Adverse Reaction- Bravecto 1000 mg was administered to a pregnant dog in February 2015 and on approximately 18 March 2015, the dog gave birth (her first litter) to 6 puppies. One of these puppies had a birth defect (organs out of the abdominal cavity) and died. No treatment was done. The female dog (dam) was unaffected. The owner also reported cases #2015-BR-00653 and #2015-BR-00654. No more information is expected.

CASE TWO - 10 PUPPIES ALL DIED WITHIN 24 HOURS DEVELOPED DROOLING
Suspected Adverse Reaction: Bravecto 1400 mg was administered to a pregnant dog (at 45 days of pregnancy) on 14 Sep 2015. On 27 Sep 2015, when the female was at 58 days of pregnancy, she gave birth to 10 puppies; however, all developed drooling and died 24 hours later. The only potential exposure of the puppies to Bravecto was in utero. No treatment was done and no tests or necropsy were done.

CASE THREE - PREMATURE DELIVERY
Suspected Adverse Reaction: Bravecto 112.5 mg was administered to a dog in September 2015 and 15 days before the expected date of birth, this female gave birth to 4 dogs. There was no treatment and the outcome of reaction to the female is unknown.

CASE FOUR - PREMATURE DELIVERY
Suspected Adverse Reaction: Bravecto 500 mg was administered to a pregnant female dog in December 2015 and approximately 5 days later, she had premature parturition (at 50 days of gestation) and gave birth to10 premature puppies. However, all the puppies died (the specific date(s) was/were not reported). No treatment was done and the outcome of the female dog (dam) is unknown. No necropsies were done in the puppies.

CASE FIVE - SEVEN PUPPIES DIED AFTER LACTATING - FROM ONE TO THREE DAYS AFTER ADMINISTRATION
Suspected adverse reaction: On 04 Nov 2014 The American Society for the Prevention of Cruelty to Animals reported that 7 pups from a litter of 8 died 0-2 days after their lactating bitch was administered Bravecto (over 44 and up to 88 lbs) on 29 Oct 2014. One pup died during the night on the date of administration. Three pups were found dead by 2pm on 30 Oct 2014 and 3 pups were found dead by 2pm on 31 Oct 2014. No necropsy was performed. The product was not administered with food (ELU- treatment program not respected). The bitch and surviving pup remain asymptomatic.

CASE SIX - MULTIPLE DEFORMITIES AND DEATH
Suspect of Adverse Event- Bravecto 500 mg was administered to a dog (pregnant female) in November,2014 and the dog gave birth(seven puppies) and one this puppy had hydrocephalic, one had cleft palate, one with malformation of the diaphragm and four were weak. One day after parturition six these puppies died. No necropsy done. The condition of the mother of the puppies is unknown.

CASE SEVEN - LITTER OF SIX ALL DIED WITHIN 5 DAYS OF BIRTH
Suspected Adverse Reaction reported by clinic on 10 Jun 2015. A 5 year old 120 lbs gestating dog was given Bravecto 1400mg on approximately 21 May 2015. The dog is a farm dog that had 6 healthy litters in the past. 6 puppies were born on 28 May 2015. 2 pups were found dead on 29 May, 1 found dead on 30 May, 2 more found dead on 01 Jun. The last one died shortly after (all pups were dead within 5 days of birth).

CASE EIGHT - LIMB DEFORMITIES AND DEATH
Suspected Adverse Reaction: On 03 Nov 2015, a MAH sales representative was made aware of a perceived adverse reaction that occurred at a different veterinary clinic after use of Bravecto. The details surrounding this perceived reaction (that fulfill the criteria for a valid adverse event) were obtained on 25 Nov 2015. On this date, a veterinarian stated that 1 adult breeding dog was treated with Bravecto 1400 mg (on an unknown date approximately 1 year ago) and her litter of puppies (litter size unknown) had developed limb deformities (coded as birth defect). All of these affected pups died (coded as perinatal mortality). Necropsies were not performed. Four additional adult female dogs had also received Bravecto, the details of which are captured in linked case.

CASE NINE - THREE PUPS DIED WITHIN A FEW DAYS AFTER LACTATING BITCH GIVEN BRAVECTO

Suspected Adverse Reaction: On 11 Feb 2015 a boxer breeder reported that a litter of 9 pups was born on 03 Jan 2015. On 05 Jan 2015, the tails and front dew claws were docked and removed from 8 of the 9 pups in the litter. A dose of Bravecto 1000mg (over 44 and up to 88 lbs) was administered to the dam later on 05 Jan 2015. The breeder reported that 3 pups died between 06 Jan 2015 and 09 Jan 2015. Two of the pups were unthrifty runts in the litter. No necropsies were performed, and no fecal tests or diagnostics were run.

CASE TEN - ORGAN OUTSIDE ABDOMINAL CAVITY - TWO DEATHS
Suspected Adverse Reaction- Bravecto 250 mg was administered to a pregnant dog in February 2015 and on approximately 18 March 2015, the dog gave birth (her fourth litter) to 3 puppies. One of these puppies had a birth defect (organs out of the abdominal cavity) and one developed incoordination and both died. No treatment was done. The female dog(dam) was unaffected.

CASE ELEVEN - DEATH OF LABRADOR POODLE MIXES
Suspected adverse reaction: On 20 Nov 2015, a veterinarian reported (via a distributor representative and MAH company employee) that he was made aware of reports pertaining to Labrador/Poodle mixes (Labradoodles) that had died after receiving Bravecto (unknown dose, unknown dates of administration). However, details surrounding these perceived reactions are unknown (dates approximated).

CASE TWELVE - INTESTINES OUTISDE OF THE BODY; LIMB WOULD NOT EXTEND; DEATH
Suspected adverse reaction: On 29 Dec 2015, a veterinarian reported that an adult female dog had puppies born with abnormalities after she was dosed with Bravecto 1000 mg (over 44 and up to 88 lbs). The owner obtained the Bravecto from another veterinary hospital. Due to previous leg surgery, the dog underwent surgical implantation of semen at the other facility in Sep 2015, using propofol as the anesthetic. The same day the dog was dosed with its first dose of Bravecto. The dog had a planned C-section on approximately 03 Nov 2015 and had 6 pups. One pup was born with its intestines outside of its body, and it did not survive 24 hours. Another pup had a limb that would not extend but it recovered with hydrotherapy and massage. A third pup died within 24 hours of birth. The dog has had at least one uneventful litter with a different sire previously.

REPORTS MADE ON THIS GROUP TO US:

Jenny Zink (please pm me a case number if you have one for this letter so I can check and see if Merck reported this)
I had one dog that did get bred, but had the pups a week early and I lost 6 of them.

Tracy Chapman (no report to Merck to date is known)
Can l ask l give this to my pregnant girl l don't know if it had anything to do with it we had 1 pup born sleeping and 5 that were ok,The sleeping one had her brain exposed?

Vânia Maria Peixe
My female was pregnant, two weeks before birth, it took me to the vet to do all those tests that I usually do... All normal examinations, yes, I am creator of dachshund and price too much my animals. With that the vet, sent I give the bravecto, because it would be good, because I live in a villa with grass. I gave the medication and after about three weeks ago, she came to give creates... The Cubs were all born simply empipocados, one died with 5 days of life and the other with 15 days of life. I almost lost all puppies and mom. I sent the cubs to necropsy, even knowing that the active principle wouldn't show up in a stinking thing. I've had a lot of spending and it was a suffering only. The company came to tell me that they never had cases like this, and that was unique in the whole world. And I really said to me was also unheard of with 15 years of creation. After everything that I have been through, no money will pay the suffering of to see all that. I'm sure I won't use more and should be phased out of the market. That is a crime against our animals. Thank you.
Eireann
 
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Re: nexgard

Messagede LouLou le Sam 2 Avr 2016 17:59

Merci !

Pour ma part , je resterais très prudente sur une chienne gestante , et les chiots.

le risque majeur étant la piroplasmose ou la leishmaniose ou dirofilariose.

Nexguard est inutile dans ces cas , on peut essayer de protéger les chiennes en traitant les autres chiens adultes.

dans le cas d'une chienne gestante ou de chiot , mieux vaut les garder à l'abri le soir , et ne pas les sortir en foret.

Et bien sur , éplucher la bête à la recherche de tiques . ;)

Idem pour les huiles essentielles .

je vais ouvrir un sujet .
LouLou
 
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Re: nexgard

Messagede LouLou le Mar 5 Avr 2016 19:13

Bon !

J'ai pris du Frontline tri act pour mon chiot caniche.
il court partout , et se gratte un peu .
Puces ? Poils qui poussent , peau sèche.

pas de réaction , ni peau rouge.

mes deux colleys ont eu du nexguard en novembre , janvier , fin févier.

Il faudra que je leur redonne quelque chose la semaine prochaine.
LouLou
 
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